Wednesday, 30 September 2015

Smart Pills transforming the Diagnostics and Healthcare Market

Smart pills are ingestible medical devices consisting of elements such as sensors, cameras, patches and trackers that help in better diagnostics and monitoring. These unique devices can be easily swallowed and offer a non-invasive thorough examination of the gastrointestinal (GI) tract. The smart pills also enables comprehensive health monitoring of various physiological metrics and measuring medication adherence in patients. The below demo clearly indicates how to use the device to monitor your daily medicine intake.

Smart pill technology has revolutionized the field of GI diagnosis. Smart pills are likely to replace conventional diagnostic techniques such as endoscopy and colonoscopy. Capsule endoscopy is regarded as a major technical innovation, influencing investigation and management of various small bowel diseases, esophageal disorders, colonic disorders etc. Capsule endoscopes are designed to provide complete examination of GIT including images of esophagus, stomach, small intestine and large intestine.. The capsule endoscopy segment is gaining a strong foothold in the smart pills market.

The capsule endoscopy is noninvasive and causes minimal discomfort. The magnification obtained, here is of the order 1:8, which is much higher as compared to the conventional endoscopy. Various capsule endoscopes available in the market include small bowel capsule, colon capsule and esophagus capsule endoscopes. Small bowel capsule is the most commonly used capsule endoscope in patients with acute gastrointestinal bleeding or to detect symptoms of active Crohn’s disease (CD).On the other hand, esophagus capsule endoscopes are used to diagnose esophagitis and Barrett’s esophagus. 

Companies today are focusing on exploring the field of gastroenterology. Recent studies by various researchers to develop products have enabled clinicians to obtain clearer & better images of the GI tract which offers new hope for gastrointestinal cancer detection Recently, researchers from Chinese University of Hong Kong, have developed an advanced endoscope known as ‘Tadpole Endoscope (TE), which mimics the movement of tadpoles’. TE is different from existing wireless capsule endoscopes since the presence of a soft tail enables it to be guided around the GI tract remotely by a clinician. This allows for better imaging of the stomach and thereby helping in the accurate location of problems.

Recently in 2014, Given Imaging Ltd, a pioneer of capsule endoscopy received FDA clearance for PillCam COLON. The device provides new modality to ensure clear visualization of the colon in patients following incomplete colonoscopy. According to some recent studies, incomplete colonoscopies occur in approximately 750,000 patients in the United States alone every year. The number is further higher in women due to an increase in past pelvic surgeries. There is a growing demand for such devices among patients having long case history of abdominal surgery or advanced stage of diverticular disease. This non-invasive test enabled by PillCam COLON allows more people to get screened for colorectal cancer, and gives a minimally invasive, radiation-free option. These devices in the market have revolutionized colorectal cancer diagnostics and screening market worldwide. The following infographics shows how the product PillCam COLON works. 

Another key application of smart pills is patient monitoring that includes monitoring of parameters such as pH, temperature, pressure and drug adherence in patients. According to the World Health Organization (WHO) estimate, over 50% of us fail to take medicines correctly, while over 50% of drugs are prescribed or sold inappropriately. This leads to disastrous consequences, resulting in significant complications and deterioration of patient health. The situation aggravates with ageing of patients, since they often require management of one or more chronic conditions with multiple medications. The trend may also cost healthcare providers millions every year. 

To deal with such non-adherence in patients due to various reasons, Proteus Digital Health, Inc. California-based Proteus Digital Health and Otsuka Pharmaceuticals have developed smart pill having an ingestible sensor. The digital pill is first of its kind to be approved by the U.S. Food and Drug Administration (FDA) as an aid to measure medication adherence.  The new drug application accepted by FDA was for an oral tablet that combines Otsuka’s branded antipsychotic Abilify (aripiprazole) with an embedded ingestible sensor device developed by Proteus Digital Health The ingestible device consists of minuscule sensors made of silicon along with metals-magnesium and copper, present in traces. The device gets powered on when the metals come in contact with stomach acids thereby triggering the sensor to generate signals that can be picked up by a disposable bandage-like patch worn by patient. The patch relays information to a mobile phone application. The following link shows how clinicians will use FDA approved digital pill to monitor patients and facilitate effective drug delivery among them. 

With the patient’s consent, the information can be assessed by caregivers and clinicians, thus helping individuals to develop and sustain healthy habits. Furthermore, it enables medical practitioners and doctors to offer more effective, data-driven health-care. The application can track the drug's effects - whether it's been prescribed at the right dosage, or if it simply isn't having any effect on the patient’s body..

The following tweets highlights the promising features of smart pills.
There are many research studies done by market research firms which tracks the current and future market trends along with offering an insight into the key drivers and growth opportunities of the market across major regions. As per a recent report by Allied Market Research, the smart pills technology market would reach $627.1 million, globally, by 2020, registering 21.2% CAGR during the forecast period 2015-2020.

In future, technological advancements to enhance the features of smart pills such as non-invasiveness, patient convenience and real time monitoring would drive their adoption rate in patient monitoring, diagnostic imaging and drug delivery.

Monday, 17 August 2015

Health Experts Call For Funds To Boost Ebola Vaccine Shots

Last year, approximately 27,000 people were infected by the Ebola virus in West Africa. Several sources reveal that over 11,000 of them succumbed to the outbreak in 2014. The entire medical fraternity believes that effective Ebola vaccines would have saved many lives. However, the fact that the entire world now depends upon latest drugs or vaccine for the virus too cannot be ignored. This outbreak has affected mostly poor nations like Liberia, Leone and more. It was only after a public alarm; health officials from regions like Europe as well as United States paid a visit to West Africa. The sudden outbreak also persuaded scientists to develop and test potential vaccine candidates that had been awaiting consent for years. Several clinical trials in regions including Guinea too show that the latest inventions have proved fruitful.

 In addition, close to $ 8 billion was spent in Guinea, Liberia and Sierra Leone for the development of Ebola drugs and treatment reported ‘NY Times ‘.  The same source revealed that getting a vaccine costs anywhere between $500 million as well as $1 billion. These funds help several drug manufacturers or biotechnology firms and scientists that are working hard to produce vaccines but are deprived of resources to manufacture them or seek an approval. Moreover, with the ‘World Health Organization’ supporting clinical trials of the vaccine in areas including Guinea has acted as a boon for fund raising and has attracted contributions from several private companies and drug makers for new virus vaccine.

In July 2015, health experts from across the global seconded the need for creating a $2 billion Ebola virus vaccine production fund to boost new shots. Commenting on this the Welcome Trust’s director, Jeremy Farrar said "We can no longer sit back and ignore the chronic lack of progress in developing new vaccines, and improving existing ones." Jeremy was of the co – writers responsible for creating the fund. Allied Market Research has added a report titled “Global Potential Analysis of Ebola drug and Vaccines Market (Pipeline analysis, Drugs, Vaccines, and Geography) through 2020.” As per the report the vaccine manufacturing in regions such as Asia – Pacific, LAMEA, Europe and North America would observe tremendous growth.

Friday, 7 August 2015

Technology Trends Drives The Capsule Endoscopy System In 2015

Over the past few years medical sensors have become smaller. The MEMS (or Microelectrical-mechanical systems) have been popular in medical equipment, from stents to chemosensor. Even the capsule endoscopy systems comes with a miniature camera as well as radio technologies. These systems captures the images of human digestive tract from the inside. Latest discoveries in the data analytics, material science and equipment engineering collectively promise a much smaller and modish sensor. 

The recent development in miniaturization assures biocompatibility. Medical experts believe that the smaller the system, the less likely it would interfere with the immune mechanism. This is true for capsule endoscopy used to take images of the entire gastrointestinal tract. PillCam® SB launched by Covidien boasts of vitamin –sized, wireless pill design that can improve the diagnosis for small bowel diseases. Recently, a Vanderbilt University engineer, Pietro Valdastri received $1.5 million as grant to continue the development of his a unique magnetic capsule for patients with IBD.  

Besides this, miniaturization when combined with the latest electrochemical as well as optical techniques boosts specificity & sensitivity for several medical conditions or uses. For example, scientists indicate that when size of the capsule endoscopy system is reduced it allows medical professional pick up the elements on the device. The Qatar International Medical Congress held between May 26 – 28, 2015 also included video capsule endoscopy as well as many sensitive, yet important, next generation concepts on palliative care.

Apart from this, boom in data analytics have also observed some of the greatest advancements in the medical sensors industry. Medical experts now combine the sensor data with improved analytics as well as machine learning techniques to diagnose diseases accurately. Allied Market Research has published a report titled “World Capsule Endoscopy System - Market Opportunities and Forecast, 2014 – 2020.” As per the report the capsule endoscopy system would register a CAGR of 14.8 percent during the forecast period of 2014 to 2020 worldwide. The aforementioned report also uncovers there would a significant development of the capsule endoscopy system in regions such as North America, LAMEA, Asia Pacific and Europe.

Thursday, 6 August 2015

Specialty enzymes find immense application in therapeutics

Enzymes are proteins naturally produced by living organisms that stimulate and speed up bio-chemical reactions. These prove beneficial in building new cells, repairing damaged ones in the blood and tissues of organisms. As these are multifunctional and have high specificity, they find widespread applications in pharmaceutical industries, in diagnosing chronic diseases and in the treatment of various ailments including cancer, cardiovascular diseases and more. Several Industrial and household catalysis depends on the activity of enzymes as they lower activation energy and improve manufacturing efficiencies. Besides, they are cost effective and act as eco-friendly catalysts in various industrial, environmental and consumer products.

Specialty enzymes are proteins that are used in pharma, biotech & diagnostics, and act as biocatalysts in reaction, accelerating the pace of reactions thus acting as a cost-effective and eco-friendly entity in industrial and environmental products. Specialty enzymes find immense applications in areas such as molecular biology and creating molecules that have effective therapeutic uses. These enzymes are recommended by doctors to control incidences of digestive disorders, recent clinical trials point towards reliable evidences in being used as treatment therapy for diseases like cancer. Administered individually or with other treatments specialty enzymes such as prolactazyme, collagenase treats skin ulcer. Enzymes like asparaginase and streptokinase are used to treat various diseases. These enzymes are used in small amounts in therapeutics so that they do not cause any side effect. Furthermore, they must be highly purified and have a high degree of specificity. For instance alkaline phosphatase and peroxides are used in immunoassays.

Recently, researchers at the Centenary Institute in Sydney have uncovered new information about an enzyme called DPP9. They believe DPP9 is a potential therapeutic target and limits the growth of cancerous cells in liver. Currently, the molecule is highly powerful and needs to be externally regulated. Researches are also trying to ascertain how the cells of the body can achieve this naturally. Professor Mark Gorrell, who is behind the discovery of DPP9, is currently researching on the functionalities of the enzyme. There are other such endeavors undertaken by the research departments of prominent pharma industries and market analysts are observant of the growth dynamics of global specialty enzymes. Recently, a report by Allied Market Research titled “World Specialty Enzymes (Pharmaceuticals, Biotechnology R&D, Diagnostics)”. As per the report, specialty enzymes market for biotechnology research, pharmaceuticals and diagnostics was valued at $561.9 million in the year 2014 and would generate a revenue of $947.5 million by the end of 2020, growing at 9.4% CAGR amid the period 2015 - 2020.

Tuesday, 4 August 2015

Biosimilar Drugs Promises Cost Effective Treatment Even For Deadly Diseases

Follow- on biologics (FOBs) is a biological, inventor developed product that has greater similarity to biological products that has been already approved. Both approved biological medicines and FOBs have no clinical difference when it comes to the safety as well as potency of the products. The application of FOBs also popular as biosimilars in blood disorders, Oncology diseases, deficiencies in growth hormones plus may others, exhibit the greatest market potential as a result of dynamic patent scenario. 

Wider choice for biologic oncology treatment have now invaded markets including United States. The arrival of biologic for cancer treatment would help drive low cost for many of the highly –priced products in patient care. Treatments that worked as restraint for cancer’s biological substructure have undergone drastic change for some cancer types. The arrival of biosimilar now accounts for approximately ½ cancer medicine spending up from nearly 11 percent 10 years back reported IMS Institute. Recently, Hetero pharmaceuticals introduced their biosimilar medicine Rituximab in India under MABALL found effective in treating blood cancer.

In another incident the FDA recognised the first FOBs in the US. The regulatory body confirmed that the medicine Zarxio can now be used for various chemotherapy treatments. This drug aids in the production of white bloods cells in a patient’s body. Besides this, the drug is a generic make of the Neupogen. Apart from this absence of cost effective drug in the GHD treatment market also signifies great opportunity, because the latest biologics popular as biobetters is costly.

Today, FOBs are being used to a greater extent in NHS. Similarly, NICE also comprises of biosimilars in its new technology which is an appraisal on somatropin. Health professionals believe that the biosimilar drugs for hormonal deficiency would be highly accessible and become popular over the next four to five years Biosimilars provide NHS significant cost saving, majorly as they are effective for treating long – term medical conditions.

AlliedMarket Research has published a report titled “World Biosimilars/Follow-on-Biologics - Market Opportunities and Forecast, 2014 – 2020.” As per the report the FOBs industry would register a growth of nearly 49.1 percent during the forecast period 2014 to 2020.

Monday, 3 August 2015

Radial tires has revolutionized the global pneumatic tires industry

The market of tires in general is driven by the large scale manufacture of tires in automotive industry and their large adoption across passenger and industrial vehicles. Tires are highly engineered structural composites which are designed to provide good vehicle control and maneuvering, retreading and traction criteria, along with meeting safety and performance expectations of the customer.

Pneumatic tires are rubber tires filled with compressed air, the other raw materials being carbon black, steel wire, fabric, steel, polyester, nylon, and rayon, fabric cord and wires. The pneumatic tire market is largely driven by a tremendous increase in automobile production globally along with rise in the demand of tires in the replacement market.

The global pneumatic tire market is segmented based on the vehicle type, type of sale, product type and geographical locations. On the basis of type, pneumatic tires market is segmented into radial and cross-ply tires. On the basis of the type of vehicle, the global pneumatic tires market is segmented into two-wheelers, four-wheelers, aircraft, industrial vehicles, agricultural vehicles amongst others. Based on the above type, four wheelers tire segment generates the maximum revenue-generating category. Among four wheelers, pneumatic tires market is gaining prominence in being used in passenger cars, industrial vehicles and their increased adoption in transportation industry.

The advent of radial tires has revolutionized the entire market of pneumatic tires offering high growth momentum to the global pneumatic tires market. The aforementioned segment amount for 68.8% of the total tire market in terms of value in the year 2014, growing at 7.2% CAGR amid the forecast period. Sometimes radials pneumatic tires are constructed with many layers of steel belts in the tread and sidewall which easily repel sharp-cutting objects such as nails and staples. A major German automotive manufacturing company, Continental AG, has recently launched pneumatic radial tire ContiRT20 useful particularly for their larger forklifts. They offer greater resistance to puncture, have increased lateral stability and high retreading potential.

Recently, Allied market Research has published a report titled “World Pneumatic Tire - Market Opportunities and Forecasts, 2014 - 2020”. As mentioned in the report, the global pneumatic tire market is expected to contribute a revenue of $287.5 billion by the end of 2020, growing at a CAGR of 7.0% amid the period of 2015–2020.  Key companies profiled in the report are Continental AG, Michelin, Cooper Tire & Rubber Company, The Goodyear Tire and Rubber, Bridgestone Corporation, Company, Hankook Tire Co. Ltd., Sumitomo Rubber, The Yokohama Rubber Co. Ltd., Industries Ltd., and Kumho Tire USA, Inc, amongst others.

Microwave Oven Maker Focus On Design Flexibility

Worldwide, people are taking to microwave cooking, as they believe it is healthy. To woo customers, microwave brands are now offering customers more than just, traditional cooking, grilling and steaming. Furthermore, with the aim to make these appliances a powerhouse of cooking, manufacturers are considering improvements in their existing freestanding or in –built features. Quick Touch model from Breville is a finest example that offers consumers a user-friendly interface. The brand enables users to adjust power level easily and accordingly to suit a particular food type. Breville’s top –selling make secures approximately 8.7% market value share in, the over $300 price category.

Another microwave manufacturer Panasonic is busy concentrating on the convenience of use, automatic features as well as whip smart technology to help buyers reap optimum benefits from their microwaves.  The new microwave innovation from the company promises multiple cooking techniques such as latest steaming feature for nutritious, delicious food, defrost function and more. Healthy and easy to cook meals also go hand – in – hand for microwaves from Sharp. Besides convenience cooking, the appliance enable easy meal preparation for nutrition – packed food at an affordable price and the trend is significantly visible in the Australia. The latest model from Sharp come with cutting - edge features including Sensor and Flatbed features, which makes the cooking experience easy and simple.

LG Electronics too has paid attention to innovation. The brand intends to introduce easy to clean microwave ovens.  Latest model ‘32-Litre Stainless Steel Convection Oven With Grill’ from the makers come with interior made of stainless steel backed by grease removal coating. The features make cleaning completely fuss-free. The model also boasts of its humidity sensor that instantly identifies vapour and can adjust the power levels as well as meal preparation time during cooking. Allied Market Research has published a report titled “World Microwave Oven Market - Opportunities and Forecasts, 2014 – 2020.” As per the report the microwave oven industry would observe growth in regions such as LAMEA, North America, Europe and Asia –Pacific.